{"id":14644,"date":"2017-03-13T09:04:08","date_gmt":"2017-03-13T12:04:08","guid":{"rendered":"https:\/\/www.infobioquimica.com\/new\/?p=14644"},"modified":"2017-03-13T09:04:08","modified_gmt":"2017-03-13T12:04:08","slug":"chimeric-antigen-receptor-t-cell-therapy-how-it-works","status":"publish","type":"post","link":"https:\/\/www.infobioquimica.com\/new\/2017\/03\/13\/chimeric-antigen-receptor-t-cell-therapy-how-it-works\/","title":{"rendered":"Chimeric Antigen Receptor T-Cell Therapy: How it Works"},"content":{"rendered":"<p>Lymphocytes, a subtype of <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Also known as \u201cleukocytes,\u201d the five types of infectionfighting cells in the blood. These include neutrophils, eosinophils, basophils, monocytes and lymphocytes.\" data-original-title=\"White Blood Cells\">white blood cells<\/span>, comprise a major portion of the <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A system within the body that works to fight disease and infection. \" data-original-title=\"Immune system\">immune system<\/span>. There are three types of lymphocytes<\/p>\n<ul>\n<li>B lymphocytes (B cells) make <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A type of protein created by blood cells when they are invaded by bacteria, viruses, or other harmful things called antigens. Antibodies help the body fight against invaders that make people get sick. Antibodies can also be made in the lab and are used to help find certain types of cancer and in treatment. \" data-original-title=\"Antibodies\">antibodies<\/span> to fight infection<\/li>\n<li>T lymphocytes (T cells) and natural killer (NK) cells directly kill infected or cancerous cells and also talk to other cells of the <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A system within the body that works to fight disease and infection. \" data-original-title=\"Immune system\">immune system<\/span> using chemicals known as \u201c<span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Cell- (cyto-) derived chemicals that are secreted by various types of cells and act on other cells to stimulate or inhibit their function. Chemicals derived from lymphocytes are called \" data-original-title=\"Cytokines\">cytokines<\/span>.\u201d<\/li>\n<\/ul>\n<p><span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A treatment that uses the body\u2019s immune system to treat diseases. Such therapies include\n - Monoclonal antibody therapy: a type of drug using antibodies designed to attack specific parts of the cancer cells\n- Radioimmunotherapy: a type of drug that uses radioactive substances and antibodies to attack cancer cells\n- Vaccine therapy: drugs used to stimulate the immune system to fight cancer cells. \" data-original-title=\"Immunotherapy\">Immunotherapy<\/span><\/p>\n<ul>\n<li>Is a type of treatment that utilizes the body\u2019s own <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A system within the body that works to fight disease and infection. \" data-original-title=\"Immune system\">immune system<\/span> to fight cancer<\/li>\n<li>Improves the body\u2019s ability to detect and kill cancer cells<\/li>\n<li>Is based on the concept that immune cells or <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A type of protein created by blood cells when they are invaded by bacteria, viruses, or other harmful things called antigens. Antibodies help the body fight against invaders that make people get sick. Antibodies can also be made in the lab and are used to help find certain types of cancer and in treatment. \" data-original-title=\"Antibodies\">antibodies<\/span> can recognize and kill cancer cells.<\/li>\n<\/ul>\n<p>Immune cells or <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A type of protein created by blood cells when they are invaded by bacteria, viruses, or other harmful things called antigens. Antibodies help the body fight against invaders that make people get sick. Antibodies can also be made in the lab and are used to help find certain types of cancer and in treatment. \" data-original-title=\"Antibodies\">antibodies<\/span> can be produced in the laboratory under tightly controlled conditions and then given to patients to treat cancer. Several types of <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A treatment that uses the body\u2019s immune system to treat diseases. Such therapies include\n - Monoclonal antibody therapy: a type of drug using antibodies designed to attack specific parts of the cancer cells\n- Radioimmunotherapy: a type of drug that uses radioactive substances and antibodies to attack cancer cells\n- Vaccine therapy: drugs used to stimulate the immune system to fight cancer cells. \" data-original-title=\"Immunotherapy\">immunotherapy<\/span> are either approved for use or are under study in <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Careful studies done by doctors to test new drugs or treatments, or new uses for approved drugs or treatments. The goal of clinical trials for blood cancers is to improve treatment and quality of life and to find cures.\" data-original-title=\"Clinical trials\">clinical trials<\/span> to determine their effectiveness in treating various types of cancer.<\/p>\n<h4>Chimeric <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A foreign substance, mostly a protein, that creates an immune response when it is eaten, inhaled, or comes into contact with the skin or mucous membranes. Examples are bacteria, viruses and allergens. Antigens stimulate plasma cells to produce antibodies\" data-original-title=\"Antigen\">Antigen<\/span> Receptor T-Cell Therapy: How it Works<\/h4>\n<p>T cells are collected from a patient. T cells are collected via <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A process using a machine to take out needed parts of the donor\u2019s blood and return the unneeded parts to the donor. This process lets certain blood components, including red blood cells, white blood cells and platelets to be removed separately and in large volumes. See Platelet Transfusion.\" data-original-title=\"Apheresis\">apheresis<\/span>, a process that withdraws blood from the body and removes one or more blood components (such as <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"The liquid part of the blood. \" data-original-title=\"Plasma\">plasma<\/span>, <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Also known as \u201cthrombocytes,\u201d platelets are small colorless blood cells. They travel to and collect at the site of a wound. Once they get there, the platelets' sticky surface helps them to form clots and stop bleeding. Platelets make up about one tenth of the volume of red blood cells. \" data-original-title=\"Platelets\">platelets<\/span> or <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Also known as \u201cleukocytes,\u201d the five types of infectionfighting cells in the blood. These include neutrophils, eosinophils, basophils, monocytes and lymphocytes.\" data-original-title=\"White Blood Cells\">white blood cells<\/span>). The remaining blood is then returned back into the body.<\/p>\n<p>T cells are reengineered in a laboratory. The T cells are sent to a laboratory or a drug manufacturing facility where they are genetically engineered to produce chimeric <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A foreign substance, mostly a protein, that creates an immune response when it is eaten, inhaled, or comes into contact with the skin or mucous membranes. Examples are bacteria, viruses and allergens. Antigens stimulate plasma cells to produce antibodies\" data-original-title=\"Antigen\">antigen<\/span> receptors (CARs) on their surface.<\/p>\n<p>After this reengineering, the T cells are known as \u201cchimeric <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A foreign substance, mostly a protein, that creates an immune response when it is eaten, inhaled, or comes into contact with the skin or mucous membranes. Examples are bacteria, viruses and allergens. Antigens stimulate plasma cells to produce antibodies\" data-original-title=\"Antigen\">antigen<\/span> receptor (CAR) T cells.\u201d CARs are proteins that allow the T cells to recognize an <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A foreign substance, mostly a protein, that creates an immune response when it is eaten, inhaled, or comes into contact with the skin or mucous membranes. Examples are bacteria, viruses and allergens. Antigens stimulate plasma cells to produce antibodies\" data-original-title=\"Antigen\">antigen<\/span> on targeted tumor cells.<\/p>\n<p>The reengineered CAR T cells are then multiplied. The number of the patient\u2019s genetically modified T cells is \u201cexpanded\u201d by growing cells in the laboratory until there are many millions of them. These CAR T cells are frozen and, when there are enough of them, they are sent to the hospital or center where the patient is being treated.<\/p>\n<p>At the hospital or treatment center, the CAR T cells are then infused into the patient. Many patients are given a brief course of one or more <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A treatment that uses medicine (chemical agents) to kill cancer cells.\" data-original-title=\"Chemotherapy\">chemotherapy<\/span> agents before they receive the infusion of CAR T cells. CAR T cells that have been returned to the patient\u2019s bloodstream multiply in number. These are the \u201cattacker\u201d cells that will recognize, and kill, cancerous cells that have the targeted <span title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A foreign substance, mostly a protein, that creates an immune response when it is eaten, inhaled, or comes into contact with the skin or mucous membranes. Examples are bacteria, viruses and allergens. Antigens stimulate plasma cells to produce antibodies\" data-original-title=\"Antigen\">antigen<\/span> on their surface.<\/p>\n<p>The CAR T cells guard against recurrence. CAR T cells may remain in the body long after the infusion has been completed. They guard against cancer recurrence, so the therapy frequently results in long-term remissions.<\/p>\n<h4>Dr. Brentjens talks about CAR T therapy.<\/h4>\n<p><iframe loading=\"lazy\" width=\"696\" height=\"392\" src=\"https:\/\/www.youtube.com\/embed\/NEt9BmvSl0k?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<h4>Dr. Steven Rosenberg discusses saving lives with CAR T.<\/h4>\n<p><iframe loading=\"lazy\" width=\"696\" height=\"392\" src=\"https:\/\/www.youtube.com\/embed\/ZrEbAOqoGuM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>At this time, CAR T-cell therapy is only available to patients who are participating in a clinical trial. Trial protocols vary. Depending on the clinical trial, care may be provided in either a hospital setting or a treatment center. Patients may have to stay at the treatment facility, or they may need to plan to stay close by before, during or following treatment. Some trial protocols require patients to confirm the availability of a caregiver before they can enroll in the trial..<\/p>\n<h4>Possible Side Effects of CAR T-Cell Therapy<\/h4>\n<p><strong>Cytokine-Release Syndrome (CRS)<\/strong>. A serious <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"The signs or symptoms a patient may have from the effects of treatment on healthy cells.\" data-original-title=\"Side effect\">side effect<\/span> associated with CAR T-cell therapy is cytokine-release syndrome (CRS). CRS is the result of T-cell activation, so its presence actually indicates a positive response to therapy. <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Cell- (cyto-) derived chemicals that are secreted by various types of cells and act on other cells to stimulate or inhibit their function. Chemicals derived from lymphocytes are called \" data-original-title=\"Cytokines\">Cytokines<\/span> are chemical messengers that help the T cells perform their duties. With CAR T-cell therapy, large amounts of <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Cell- (cyto-) derived chemicals that are secreted by various types of cells and act on other cells to stimulate or inhibit their function. Chemicals derived from lymphocytes are called \" data-original-title=\"Cytokines\">cytokines<\/span> are produced by the activated <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A system within the body that works to fight disease and infection. \" data-original-title=\"Immune system\">immune system<\/span>. CRS in this setting may cause high fevers, low blood pressure or poor lung oxygenation (requiring administration of supplemental oxygen as a temporary measure). Some patients experience delirium, confusion and seizure while undergoing treatment. The onset of these symptoms is typically within the first week of treatment. These symptoms, however, are reversible.<\/p>\n<p><strong>B-Cell Aplasia.<\/strong> CAR T-cell therapy targeting antigens found on the surface of B cells not only destroys cancerous B cells but also normal B cells. Therefore, B cell aplasia (low numbers of B cells or absent B cells) is an expected <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"The signs or symptoms a patient may have from the effects of treatment on healthy cells.\" data-original-title=\"Side effect\">side effect<\/span>. This absence of B cells results in less ability to make the <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A type of protein created by blood cells when they are invaded by bacteria, viruses, or other harmful things called antigens. Antibodies help the body fight against invaders that make people get sick. Antibodies can also be made in the lab and are used to help find certain types of cancer and in treatment. \" data-original-title=\"Antibodies\">antibodies<\/span> that protect against infection. Intravenous immunoglobulin replacement is used to prevent infection. It is not known how long the decreased number of B cells persists however, no long-term side effects have been noted.<\/p>\n<p><strong>Tumor Lysis Syndrome (TLS).<\/strong> Another known <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"The signs or symptoms a patient may have from the effects of treatment on healthy cells.\" data-original-title=\"Side effect\">side effect<\/span> of CAR T-cell therapy is tumor lysis syndrome (TLS), a group of metabolic complications that can occur due to the breakdown of dying cells\u2014usually at the onset of toxic cancer treatments. However, TLS can occur one month or more after CAR T-cell therapy. TLS can be a life-threatening complication of any treatment that causes breakdown of cancer cells, including CAR T cells. The complication has been managed by standard supportive therapy.<\/p>\n<h4>Results, Limitations, and the Future of CAR T-cell Therapy<\/h4>\n<p>Early results from CAR T-cell trials have generated impressive results and considerable promise in patients with blood cancers.<\/p>\n<p><strong>Acute <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A term used to describe a type of blood cell disease caused by young or immature lymphocytes or \" data-original-title=\"Lymphoblastic\">lymphoblastic<\/span> <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A cancer of the marrow and blood. There are four main subtypes of leukemia: acute lymphoblastic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia and chronic myeloid leukemia.\" data-original-title=\"Leukemia\">leukemia<\/span> (ALL). <\/strong>CAR T-cell therapy may represent options for ALL patients who have relapsed after intensive <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A treatment that uses medicine (chemical agents) to kill cancer cells.\" data-original-title=\"Chemotherapy\">chemotherapy<\/span> or a stem cell transplant. In some studies, up to 90 percent of children and adults with ALL who had either relapsed multiple times, or failed to respond to standard therapies, achieved <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"When signs of a disease disappear. This usually follows treatment. The words \u201ccomplete\u201d and \u201cpartial\u201d are sometimes used to further define the term \u201cremission.\u201d Complete remission means that all evidence of the disease is gone. Partial remission means that the disease is markedly improved by treatment, but residual evidence of the disease is present\" data-original-title=\"Remission\">remission<\/span> after receiving CAR T-cell therapy.<\/p>\n<p><strong>Other blood cancers. <\/strong>Studies of CAR T-cell therapy in other blood cancers, including chronic lymphocytic <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A cancer of the marrow and blood. There are four main subtypes of leukemia: acute lymphoblastic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia and chronic myeloid leukemia.\" data-original-title=\"Leukemia\">leukemia<\/span> (CLL), some types of non-Hodgkin <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Lymphoma is the name for a group of blood cancers that develop in the lymphatic system. The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma (NHL).\" data-original-title=\"Lymphoma\">lymphoma<\/span> (NHL) including diffuse large B cell <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Lymphoma is the name for a group of blood cancers that develop in the lymphatic system. The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma (NHL).\" data-original-title=\"Lymphoma\">lymphoma<\/span> (DLBCL) and follicular <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Lymphoma is the name for a group of blood cancers that develop in the lymphatic system. The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma (NHL).\" data-original-title=\"Lymphoma\">lymphoma<\/span>, as well as multiple <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A type of cancer that begins in the bone marrow. It is a cancer of plasma cells, which are a type of white blood cells (also called plasma B cells). \" data-original-title=\"Myeloma\">myeloma<\/span>, are also very promising.<\/p>\n<p>While data is fast emerging as to the early responses to CAR T-cell therapy, most of the patients participating in these <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Careful studies done by doctors to test new drugs or treatments, or new uses for approved drugs or treatments. The goal of clinical trials for blood cancers is to improve treatment and quality of life and to find cures.\" data-original-title=\"Clinical trials\">clinical trials<\/span> have only been followed for a relatively short period of time. Following these trial participants over the long term will provide information as to the length of their responses. It is important for more pediatric and adult patients to be enrolled in <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Careful studies done by doctors to test new drugs or treatments, or new uses for approved drugs or treatments. The goal of clinical trials for blood cancers is to improve treatment and quality of life and to find cures.\" data-original-title=\"Clinical trials\">clinical trials<\/span>. Larger study samples, looked at over more extended periods, will help researchers further understand the impact of this type of therapy, ways to reduce its toxicity and also improve toxicity management.<\/p>\n<h4>Enrolling in a Trial<\/h4>\n<p>Talk with your doctor about whether participation in a CAR T-cell therapy clinical trial is an option for you. Obtaining another opinion from a <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A doctor who specializes in blood cell diseases.\" data-original-title=\"Hematologist\">hematologist<\/span>&#8211;<span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"A cancer doctor. \" data-original-title=\"Oncologist\">oncologist<\/span> (a blood cancer specialist), may be helpful in finding additional clinical-trial information as well. When you discuss CAR T-cell therapy as a potential treatment option for you, it may be helpful to have<\/p>\n<ul>\n<li>A list of questions to ask concerning risks versus benefits of such a trial (<a class=\"\" href=\"https:\/\/www.lls.org\/managing-your-cancer\/communicating-with-your-specialist\/printable-question-guides\" target=\"_blank\">click here<\/a> for lists of suggested questions).<\/li>\n<li>A family member, friend, or another advocate with you for support and to take notes.<\/li>\n<\/ul>\n<p>In addition to speaking with your doctor, LLS Information Specialists, available at (800) 955-4572, offer guidance on how patients can work with their doctors to determine if a specific clinical trial is an appropriate treatment option. Information Specialists can search for <span class=\"test\" title=\"\" data-toggle=\"popover\" data-trigger=\"hover\" data-placement=\"top\" data-content=\"Careful studies done by doctors to test new drugs or treatments, or new uses for approved drugs or treatments. The goal of clinical trials for blood cancers is to improve treatment and quality of life and to find cures.\" data-original-title=\"Clinical trials\">clinical trials<\/span> on behalf of patients, family members and healthcare professionals.<\/p>\n<p><strong>Source:<\/strong> <a href=\"https:\/\/www.lls.org\/treatment\/types-of-treatment\/immunotherapy\/chimeric-antigen-receptor-car-t-cell-therapy\" target=\"_blank\">lls.org<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lymphocytes, a subtype of white blood cells, comprise a major portion of the immune system. There are three types of lymphocytes B lymphocytes (B cells) make antibodies to fight infection T lymphocytes (T cells) and natural killer (NK) cells directly kill infected or cancerous cells and also talk to other cells of the immune system [&hellip;]<\/p>\n","protected":false},"author":2620,"featured_media":14645,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"twitterCardType":"summary_large_image","cardImageID":0,"cardImage":"","cardTitle":"","cardDesc":"","cardImageAlt":"","cardPlayer":"","cardPlayerWidth":0,"cardPlayerHeight":0,"cardPlayerStream":"","cardPlayerCodec":"","footnotes":""},"categories":[655],"tags":[5513,23011,23017,23005,23009,23003,23007,9864,22999,5507,4557,23015,23001,23013],"class_list":["post-14644","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-ingles","tag-antibodies","tag-b-lymphocytes-b-cells","tag-cancerous-cells","tag-car-t-cell-therapy","tag-chimeric-antigen-receptor-t-cell-therapy","tag-chronic-lymphocytic-leukemia-cll","tag-cytokine-release-syndrome-crs","tag-cytokines","tag-diffuse-large-b-cell-lymphoma-dlbcl","tag-immune-cells","tag-immune-system","tag-natural-killer-nk","tag-non-hodgkin-lymphoma-nhl","tag-t-lymphocytes-t-cells"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/14644","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/users\/2620"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/comments?post=14644"}],"version-history":[{"count":1,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/14644\/revisions"}],"predecessor-version":[{"id":14646,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/14644\/revisions\/14646"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/media\/14645"}],"wp:attachment":[{"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/media?parent=14644"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/categories?post=14644"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/tags?post=14644"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}