{"id":25049,"date":"2020-10-19T12:47:51","date_gmt":"2020-10-19T15:47:51","guid":{"rendered":"https:\/\/www.infobioquimica.com\/new\/?p=25049"},"modified":"2020-10-19T12:47:54","modified_gmt":"2020-10-19T15:47:54","slug":"sars-cov-2-positivity-rates-associated-with-circulating-25-hydroxyvitamin-d-levels","status":"publish","type":"post","link":"https:\/\/www.infobioquimica.com\/new\/2020\/10\/19\/sars-cov-2-positivity-rates-associated-with-circulating-25-hydroxyvitamin-d-levels\/","title":{"rendered":"SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels"},"content":{"rendered":"<p>Until treatment and vaccine for coronavirus disease-2019 (COVID-19) becomes widely available, other methods of reducing infection rates should be explored. This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity rates. Over 190,000 patients from all 50 states with SARS-CoV-2 results performed mid-March through mid-June, 2020 and matching 25(OH)D results from the preceding 12 months were included. Residential zip code data was required to match with US Census data and perform analyses of race\/ethnicity proportions and latitude. A total of 191,779 patients were included (median age, 54 years [interquartile range 40.4\u201364.7]; 68% female. The SARS-CoV-2 positivity rate was 9.3% (95% C.I. 9.2\u20139.5%) and the mean seasonally adjusted 25(OH)D was 31.7 (SD 11.7). The SARS-CoV-2 positivity rate was higher in the 39,190 patients with \u201cdeficient\u201d 25(OH)D values (&lt;20 ng\/mL) (12.5%, 95% C.I. 12.2\u201312.8%) than in the 27,870 patients with \u201cadequate\u201d values (30\u201334 ng\/mL) (8.1%, 95% C.I. 7.8\u20138.4%) and the 12,321 patients with values \u226555 ng\/mL (5.9%, 95% C.I. 5.5\u20136.4%). The association between 25(OH)D levels and SARS-CoV-2 positivity was best fitted by the weighted second-order polynomial regression, which indicated strong correlation in the total population (R<sup>2<\/sup>\u00a0= 0.96) and in analyses stratified by all studied demographic factors. The association between lower SARS-CoV-2 positivity rates and higher circulating 25(OH)D levels remained significant in a multivariable logistic model adjusting for all included demographic factors (adjusted odds ratio 0.984 per ng\/mL increment, 95% C.I. 0.983\u20130.986; p&lt;0.001). SARS-CoV-2 positivity is strongly and inversely associated with circulating 25(OH)D levels, a relationship that persists across latitudes, races\/ethnicities, both sexes, and age ranges. Our findings provide impetus to explore the role of vitamin D supplementation in reducing the risk for SARS-CoV-2 infection and COVID-19 disease.<\/p><p>Authors: Harvey W. Kaufman, Justin K. Niles, Martin H. Kroll, Caixia Bi, Michael F. Holick<\/p><p>Published: September 17, 2020 <\/p><p>https:\/\/doi.org\/10.1371\/journal.pone.0239252<\/p><p><\/p><h4 class=\"wp-block-heading\"><a rel=\"noreferrer noopener\" href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0239252\" target=\"_blank\">Click here to read the article<\/a>.<\/h4><p><\/p>","protected":false},"excerpt":{"rendered":"<p>Until treatment and vaccine for coronavirus disease-2019 (COVID-19) becomes widely available, other methods of reducing infection rates should be explored. This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity [&hellip;]<\/p>\n","protected":false},"author":2620,"featured_media":24816,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"twitterCardType":"","cardImageID":0,"cardImage":"","cardTitle":"","cardDesc":"","cardImageAlt":"","cardPlayer":"","cardPlayerWidth":0,"cardPlayerHeight":0,"cardPlayerStream":"","cardPlayerCodec":"","footnotes":""},"categories":[655],"tags":[],"class_list":["post-25049","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-ingles"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/25049","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/users\/2620"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/comments?post=25049"}],"version-history":[{"count":1,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/25049\/revisions"}],"predecessor-version":[{"id":25050,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/25049\/revisions\/25050"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/media\/24816"}],"wp:attachment":[{"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/media?parent=25049"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/categories?post=25049"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infobioquimica.com\/new\/wp-json\/wp\/v2\/tags?post=25049"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}